The Interactions between Food and Drug

Classification drug-food interactions can be achieved by several criteria: their frequency; clinical significance; the mechanism by which are produced; consequence on the body; the pharmacokinetic occurring; level that is distributed. An interaction is considered clinically significant if the answer alters or compromise nutritional status of the body. The clinical consequences of the interaction refer to disruption pharmacokinetics of drugs or nutrients. Drug-nutrient interactions can be evaluated as disturbances in pharmacokinetic and pharmacodynamic action rarely the drug. Drugs and nutrients can influence signal transduction during impacting drug metabolizing enzymes and transporters on receptor-mediated gene expression. It is known that some drugs are used as substrates, inducers and inhibitors of transporters, enzymes of different tissues, the development of direct or indirect interactions with nutrients; these interactions must be known or planned to reduce the impact on the body is produced [1].